2024
94. Katayama S*, Watanabe M, Kato Y, Nomura W, Yamamoto T*.
"Engineering of Zinc Finger Nucleases Through Structural Modeling Improves Genome Editing Efficiency in Cells."
Adv. Sci. (Weinh) 2024, in press.🔗
"Engineering of Zinc Finger Nucleases Through Structural Modeling Improves Genome Editing Efficiency in Cells."
Adv. Sci. (Weinh) 2024, in press.🔗
93. Kimura T*, Maeda H, Hagiwara M, Hashimoto Y, Nakamura N, Nomura W, Tanabe T, Kobayashi M, Yamamoto M, Matsushima T, Asahara H, Kishida A.
"Evaluation of Proinflammatory Response to Polymeric Materials Using a Macrophage Cell Line Genetically Tagged with a Luminescent Peptide."
Adv. Biomed. Eng. 13, 43-51, 2024.🔗
"Evaluation of Proinflammatory Response to Polymeric Materials Using a Macrophage Cell Line Genetically Tagged with a Luminescent Peptide."
Adv. Biomed. Eng. 13, 43-51, 2024.🔗
92. Kobayakawa T, Takano H, Ishii T, Bolah P, Tsuji K, Ohashi N, Nomura W, Furuta T, Tamamura H*. "Effect of two-photon excitation to 8-azacoumarin derivatives as photolabile protecting groups."
Chem. Pharm. Bull. 72, 311-312, 2024.🔗
This article was selected as a "Featured article".
Chem. Pharm. Bull. 72, 311-312, 2024.🔗
This article was selected as a "Featured article".
91. Toda S, Hashimoto Y, Nakamura N, Yamada M, Nakaoka R, Nomura W, Yamamoto M, Kimura T,
Kishida A*.
"Effects of Polymeric Materials on Activation of THP-1 Cell-derived Macrophages during Differentiation Induced by PMA."
Adv. Biomed. Eng. 13, 1-10, 2024.🔗
Kishida A*.
"Effects of Polymeric Materials on Activation of THP-1 Cell-derived Macrophages during Differentiation Induced by PMA."
Adv. Biomed. Eng. 13, 1-10, 2024.🔗
90. Matsumoto D, Matsugi E, Kishi K, Inoue Y, Nigorikawa K, Nomura W*.
"SpCas9-HF1 Enhances Accuracy of Cell Cycle-dependent Genome Editing by Increasing HDR Efficiency, and by Reducing Off-target Effects and Indel Rates."
Molecular Therapy -Nucleic Acids 35, 102124, 2024.🔗
"SpCas9-HF1 Enhances Accuracy of Cell Cycle-dependent Genome Editing by Increasing HDR Efficiency, and by Reducing Off-target Effects and Indel Rates."
Molecular Therapy -Nucleic Acids 35, 102124, 2024.🔗
89. Kobayashi D, Denda M, Hayashi J, Hidaka K, Kohmura Y, Tsunematsu T, Nishino K, Yoshikawa H, Ohkawachi K, Nigorikawa K, Yoshimaru T, Ishimaru N, Nomura W, Katagiri T, Kosako H, Otaka A*.
"Sulfoxide-mediated Cys-Trp-selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization."
ChemRxiv 2024.🔗
"Sulfoxide-mediated Cys-Trp-selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization."
ChemRxiv 2024.🔗
2023
87. Matsumoto D & Nomura W*.
"The History of Genome Editing: Advances from the Interface of Chemistry and Biology."
ChemComm 59, 7676-7684, 2023.🔗
"The History of Genome Editing: Advances from the Interface of Chemistry and Biology."
ChemComm 59, 7676-7684, 2023.🔗
86. Matsumoto D, Kishi K, Matsugi E, Inoue Y, Nigorikawa K, Nomura W*.
"Cas9-Geminin and Cdt1-fused Anti-CRISPR Protein Synergistically Increase Editing Accuracy."
FEBS Lett. 597, 985-994, 2023.🔗
"Cas9-Geminin and Cdt1-fused Anti-CRISPR Protein Synergistically Increase Editing Accuracy."
FEBS Lett. 597, 985-994, 2023.🔗
85. Negi S*, Imanishi M, Hamori M, Kawahara-Nakagawa Y, Nomura W, Kishi K, Shibata N, Sugiura Y.
"The Past, Present, and Future of Artificial Zinc Finger Proteins: Design Strategies and Chemical and Biological Applications."
J. Bioinorg. Chem. 28, 249-261, 2023.🔗
"The Past, Present, and Future of Artificial Zinc Finger Proteins: Design Strategies and Chemical and Biological Applications."
J. Bioinorg. Chem. 28, 249-261, 2023.🔗
2022
84. 野村 渉*，玉村 啓和
「HIV-1阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」
BIOINDUSTRY【特集】ペプチド医薬の最新動向 ～広い観点からのペプチド創薬科学～ 39 (5), 15-25, 2022. 🔗
「HIV-1阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」
BIOINDUSTRY【特集】ペプチド医薬の最新動向 ～広い観点からのペプチド創薬科学～ 39 (5), 15-25, 2022. 🔗
2021
83. Tsuji K, Ishii T, Kobayakawa T, Ohashi N, Nomura W, Tamamura H*.
"Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones."
Org. Biomol. Chem. 19, 8264-8271, 2021. 🔗
"Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones."
Org. Biomol. Chem. 19, 8264-8271, 2021. 🔗
82. Matsumoto D & Nomura W*.
”Molecular Switch Engineering for Precise Genome Editing.”
Bioconjugate Chem. 32, 639-648, 2021. 🔗
”Molecular Switch Engineering for Precise Genome Editing.”
Bioconjugate Chem. 32, 639-648, 2021. 🔗
81. Arafiles JVV, Hirose H, Hirai Y, Kuriyama M, Sakyiamah MM, Nomura W, Sonomura K, Imanishi M, Otaka A, Tamamura H, Futaki S.
"Discovery of a Macropinocytosis-Inducing Peptide Potentiated by Medium-Mediated Intramolecular Disulfide Formation."
"Discovery of a Macropinocytosis-Inducing Peptide Potentiated by Medium-Mediated Intramolecular Disulfide Formation."
Angew. Chem., Int. Ed. 60, 11928-11936, 2021. 🔗
2020
80. Matsumoto D, Tamamura H, Nomura W*.
"A Cell Cycle-dependent CRISPR-Cas9 Activation System Based on an Anti-CRISPR Protein Shows Improved Genome Editing Accuracy."
Commun. Biol. 3, 601, 2020. 🔗
"A Cell Cycle-dependent CRISPR-Cas9 Activation System Based on an Anti-CRISPR Protein Shows Improved Genome Editing Accuracy."
Commun. Biol. 3, 601, 2020. 🔗
79. Kobayakawa T, Takano H, Ishii T, Tsuji K, Ohashi N, Nomura W, Furuta T, Tamamura H*.
"Synthesis of Hydrophilic Caged DAG-lactone for Chemical Biology Applications."
Org. Biomol. Chem. 18, 4217-4223, 2020. 🔗
"Synthesis of Hydrophilic Caged DAG-lactone for Chemical Biology Applications."
Org. Biomol. Chem. 18, 4217-4223, 2020. 🔗
78. Matsumoto D, Tamamura H, Nomura W*.
"TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases."
Biochemistry 59, 197-204, 2020. 🔗
This article is part of the "Future of Biochemistry: The Asia-Pacific Issue" special issue.
"TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases."
Biochemistry 59, 197-204, 2020. 🔗
This article is part of the "Future of Biochemistry: The Asia-Pacific Issue" special issue.
2019
77. Kobayakawa T, Ebihara K, Honda Y, Fujino M, Nomura W, Yamamoto N, Murakami T, Tamamura H*. C34 Dimeric Derivatives Utilizing Disulfide Bridges as Novel HIV-1 Fusion Inhibitors. ChemBioChem 20, 2101-2108, 2019. 🔗
76. Sakyiamah MM, Nomura W, Kobayakawa T, Tamamura H*. Development of a NanoBRET-based Sensitive Screening Method for CXCR4 Ligands. Bioconjugate Chem. 30, 1442-1450, 2019. 🔗
75. Sakyiamah MM, Kobayakawa T, Fujino M, Konno M, Narumi T, Tanaka T, Nomura W, Yamamoto N, Murakami T, Tamamura H*. Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands. Bioorg Med Chem. 27, 1130-1138, 2019. 🔗
74. Matsuda K, Kobayakawa T, Tsuchiya K, Hattori S, Nomura W, Gatanaga H, Yoshimura K, Oka S, Endo Y, Tamamura H, Mitsuya H, Maeda K*. Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C–induced HIV latency reversal. J. Biol. Chem. 294, 116-129, 2019. 🔗
2018
73. Nomura W*, Matsumoto D, Sugii T, Kobayakawa T, Tamamura H. Efficient and Orthogonal Transcription Regulation by Chemically Inducible Artificial Transcription Factors. Biochemistry 57, 6452-6459, 2018. 🔗
72. Toyama K, Kobayakawa T, Nomura W, Tamamura H*. Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Chem. Pharm. Bull. 66, 1083-1089, 2018. 🔗
71. Toyama K, Nomura W, Kobayakawa T, Tamamura H*. Delivery of a Pro-apoptotic Peptide to EGFR-positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Bioconjugate Chem. 29, 2050-2057, 2018. 🔗
70. Kobayakawa T, Matsuzaki Y, Hozumi K, Nomura W, Nomizu M, Tamamura H*. Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application. ACS Med. Chem. Lett., 9, 6-10, 2018. 🔗
69. 野村 渉*：「ゲノム編集がもたらす蛍光バイオイメージングの革新」 Precision Medicine 10月創刊号「研究者の最新動向」 1, 80-85, 2018.
68. Nomura W* Development of toolboxes for precision genome/epigenome editing and imaging of epigenetics. The Chemical Records 12; 1717-1726, 2018. 🔗
2017
67. Ohashi N, Kobayashi R, Nomura W, Kobayakawa T, Czikora A, Herold B, Lewin N, Blumberg PM, Tamamura H*. Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-lactones as PKC Ligands. Bioconjugate Chem. 28, 2135-2144, 2017. 🔗
66. Takano H, Narumi T, Nomura W, Tamamura H*. Microwave-assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization. J. Org. Chem. 82, 2739-2744, 2017. 🔗
65. Tanaka T, Aoki T, Nomura W, Tamamura H*. Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-chemotactic Activity against Jurkat Cells. J. Pept. Sci. 23, 574-580, 2017. 🔗
64. Mizuguchi T, Ohashi N, Matsumoto D, Hashimoto C, Nomura W, Yamamoto N, Murakami T, Tamamura H*. Development of Anti-HIV Peptides Based on a Viral Capsid Protein. Biopolymers (Pept. Sci.) 108, e22920, 2017. 🔗
63. 野村 渉*. DNAメチル化制御から精密エピゲノム編集へ. MEDCHEM NEWS 27, 200-207, 2017. 🔗
62. 野村 渉*.生体分子間相互作用を基盤とする機能分子の創製とケミカルバイオロジーへの展開. Yakugaku Zasshi 137, 1223-1231, 2017. 🔗
2016
61. Toyama K, Mizuguchi T, Nomura W, Tamamura H*. Functional Evaluation of Fluorescein-labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization. Bioorg. Med. Chem. 24, 3406-3412, 2016.
60. Ohashi N, Harada S, Mizuguchi T, Irahara Y, Yamada Y, Kotani M, Nomura W, Matsushita S, Yoshimura K, Tamamura H*. Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors. ChemMedChem 11, 940-946, 2016. 🔗
59. Mizuguchi T, Harada S, Miura T, Ohashi N, Narumi T, Mori H, Irahara Y, Yamada Y, Nomura W, Matsushita S, Yoshimura K, Tamamura H*. A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor. Bioorg. Med. Chem. Lett. 26, 397-400, 2016. 🔗
58. Nomura W, Mizuguchi T, Tamamura H* Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines. Biopolymers (Pept. Sci.) 106, 622-628, 2016. 🔗
57. 野村 渉，玉村 啓和：「多価型CXCR4リガンドの創製とがん細胞イメージング・検出」 医学のあゆみ 第5土曜特集「GPCR研究の最前線2016」 （医歯薬出版株式会社 東京）, 256 (5), 430-437, 2016.
2015
56. Takano H, Narumi T, Nomura W, Furuta T, Tamamura H*. Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group. Org. Lett. 17, 5372-5375, 2015. 🔗
55. Nomura W, Aikawa H, Taketomi S, Tanabe M, Mizuguchi T, Tamamura H*. Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-type CXCR4 Ligands. Bioorg. Med. Chem. 23, 6967-6973, 2015.
54. Nomura W, Koseki T, Ohashi N, Mizuguchi T, Tamamura H*. Trivalent Ligands for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression. Org. Biomol. Chem. 13, 8734-8739, 2015. 🔗
53. Mizuguchi T, Ohashi N, Nomura W, Komoriya M, Hashimoto C, Yamamoto N, Murakami T, Tamamura H*. Anti-HIV Screening for Cell-penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins. Bioorg. Med. Chem. 23, 4423-4427, 2015.
52. Nomura W, Ohashi N, Mori A, Tamamura H*. An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-penetrating Peptides. Bioconjugate Chem. 26, 1080-1085, 2015. 🔗
51. 野村 渉* ：「人工酵素によるゲノム編集工学とその応用、可能性」Yakugaku Zasshi 135; 405-414, 2015. 🔗
2014
50. Ohashi N, Nomura W, Minato N, Tamamura H*. Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer. Chem. Pharm. Bull. 62; 1019-1025, 2014.
49. Yamamoto J, Maeda N, Komiya C, Tanaka T, Denda M, Ebisuno K, Nomura W, Tamamura H, Sato Y, Yamauchi A, Shigenaga A, Otaka A*. Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker. Tetrahedron 70; 5122-5127, 2014.
48. Takano H, Narumi T, Ohashi N, Suzuki A, Furuta T, Nomura W, Tamamura H*. Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups. Tetrahedron 70; 4400-4404, 2014.
47. Yamamoto J, Denda M, Maeda N, Kita M, Komiya C, Tanaka T, Nomura W, Tamamura H, Sato Y, Yamauchi A, Shigenaga A*, Otaka A*. Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins. Org. Biomol. Chem. 12; 3821-3826, 2014.
46. 野村 渉，玉村 啓和* ：「ターゲットタンパク質を特異的に認識するプローブ」 化学工業 65; 8-14, 2014. 🔗
2013
45. Hashimoto C, Narumi T, Otsuki H, Hirota Y, Arai H, Yoshimura K, Harada S, Ohashi N, Nomura W, Miura T, Igarashi T, Matsushita S, Tamamura H*. A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics. Bioorg. Med. Chem.21, 7884-7889, 2013.
44. Hashimoto C, Nomura W, Narumi T, Fujino M, Nakahara T, Yamamoto N, Murakami T, Tamamura H*. CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies. Bioorg. Med. Chem. 21; 6878-6885, 2013.
43. Hashimoto C, Nomura W, Narumi T, Fujino M, Tsutsumi H, Haseyama M, Yamamoto N, Murakami T, Tamamura H*. Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4. ChemMedChem 8; 1668-1672, 2013.
42. Nomura W, Aikawa H, Ohashi N, Urano E, Métifiot M, Fujino M, Maddali K, Ozaki T, Nozue A, Narumi T, Hashimoto C, Tanaka T, Pommier Y, Yamamoto N, Komano JA, Murakami T, Tamamura H*. Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products. ACS Chem. Biol. 8; 2235-2244, 2013. 🔗
41. Nomura W, Hashimoto C, Suzuki T, Ohashi N, Fujino M, Murakami T, Yamomoto N, Tamamura H*. Multimerized CHR-Derived Peptides as HIV-1 Fusion Inhibitors. Bioorg. Med. Chem. 21; 4452-4458, 2013.
40. Narumi T, Arai H, Yoshimura K, Harada S, Hirota Y, Ohashi N, Hashimoto C, Nomura W, Matsushita S, Tamamura H*. CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents. Bioorg. Med. Chem. 21; 2518-2526, 2013.
39. Narumi T, Aikawa H, Tanaka T, Hashimoto C, Ohashi N, Nomura W, Kobayakawa T, Takano H, Hirota Y, Murakami T, Yamamoto N, Tamamura H*. Low-Molecular-Weight CXCR4 Ligands with Variable Spacers. ChemMedChem 8; 118-124, 2013.
38. Ohashi N, Nomura W, Narumi T, Tamamura H. Peptide-Based Ligand Screening and Function Analysis of Protein Kinase C. Biopolymers (Pept. Sci.)100; 613-620, 2013.
2012
37. Narumi T, Tanaka T, Hashimoto C, Nomura W, Aikawa H, Sohma A, Itotani K, Kawamata M, Murakami T, Yamamoto N, Tamamura H*. Pharmacophore-Based Small Molecule CXCR4 Ligands. Bioorg. Med. Chem. Lett. 22; 4169-4172, 2012.
36. Hashimoto C, Nomura W*, Ohya A, Urano E, Miyauchi K, Narumi T, Aikawa H, Komano JA, Yamamoto N, Tamamura H*. Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines. Bioorg. Med. Chem. 20; 3287-3291, 2012.
35. Nomura W*, Masuda A, Ohba K, Urabe A, Ito N, Ryo A, Yamamoto N, Tamamura H*. Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System. Biochemistry 51; 1510-1517, 2012. 🔗
34. Nomura W, Hashimoto C, Ohya A, Miyauchi K, Urano E, Tanaka T, Narumi T, Nakahara T, Komano JA, Yamamoto N, Tamamura H*. Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency. ChemMedChem 7; 205-208, 2012. 🔗
33. Narumi T, Komoriya M, Hashimoto C, Wu H, Nomura W, Suzuki S, Tanaka T, Chiba J, Yamamoto N, Murakami T, Tamamura H*. Conjugation of Cell-penetrating Peptides Leads to Identification of Anti-HIV Peptides from Matrix Proteins. Bioorg. Med. Chem. 20; 1468-1474, 2012.
32. 野村 渉，田中 智博，玉村 啓和：「HIV阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」 pp101-107，ペプチド医薬の最前線，（株）シーエムシー出版，2012.
31. 野村 渉、田中 智博、相川 春夫、玉村 啓和：「多価結合型GPCRリガンドの合成とがん細胞イメージングへの応用」 pp267-273，最新ペプチド合成技術とその創薬研究への応用，（株）メディカルドゥ，2012.
2011
30. Narumi T, Arai H, Yoshimura K, Harada S, Nomura W, Matsushita S, Tamamura H*. Small Molecular CD4 Mimics as HIV Entry Inhibitors. Bioorg. Med. Chem. 19; 6735-6742, 2011.
29. Nomura W, Ohashi N, Okuda Y, Narumi T, Ikura T, Ito N, Tamamura H*. Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore. Bioconjugate Chem. 22; 923-930, 2011. 🔗
28. Nomura W, Narumi T, Serizawa Y, Ohashi N, Lewin NE, Blumberg PM, Furuta T, Tamamura H*. Synthetic Caged DAG-lactones for Photochemically-Controlled Activation of Protein Kinase C. ChemBioChem 12; 535-539, 2011. 🔗
27. Tanaka T, Narumi T*, Ozaki T, Sohma A, Ohashi N, Hashimoto C, Itotani K, Nomura W, Murakami T, Yamamoto N, Tamamura H*. Azamacrocyclic-Metal Complexes as CXCR4 Antagonists. ChemMedChem 6; 834-839, 2011.
26. Tsutsumi H, Abe S, Mino T, Nomura W, Tamamura H*. Intense Blue Fluorescence in a Leucine Zipper Assembly. ChemBioChem 12; 691-694, 2011.
25. Ohashi N, Nomura W*, Narumi T, Lewin NE, Itotani K, Blumberg PM, Tamamura H*. Fluorescent-Responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding. Bioconjugate Chem. 22; 82-87, 2011. 🔗
24. Hashimoto C, Tanaka T, Narumi T, Nomura W, Tamamura H. The Success and Failures of HIV Drug Discovery. Expert Opin. Drug Discovery, 6; 1067-1090, 2011.
2010
23. Tanaka T, Nomura W*, Narumi T, Masuda A, Tamamura H*. Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of Dimerization State in Cells. J. Am. Chem. Soc. 132; 15899-15901, 2010. 🔗
22. Nomura W, Mino T, Narumi T, Ohashi N, Masuda A, Hashimoto C, Tsutsumi H, Tamamura H*. Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins. Biopolymers (Pept. Sci.) 94; 843-852, 2010.
21. Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H*. Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products. J. Med. Chem. 53; 5356-5360, 2010.
20. Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H*. Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products: Structure-Activity Relationship Studies. Bioorg. Med. Chem. 18; 6771-6775, 2010.
19. Narumi T, Ochiai C, Yoshimura K, Harada S, Tanaka T, Nomura W, Arai H, Ozaki T, Ohashi N, Matsushita S, Tamamura H*. CD4 Mimics Targeting the HIV Entry Mechanism and their Hybrid Molecules with a CXCR4 Antagonist. Bioorg. Med. Chem. Lett. 20; 5853–5858, 2010.
18. Nakahara T, Nomura W*, Ohba K, Ohya A, Tanaka T, Hashimoto C, Narumi T, Murakami T, Yamamoto N, Tamamura H*. Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies. Bioconjugate Chem. 21; 709-714, 2010. 🔗
17. Yamada Y, Ochiai C, Yoshimura K, Tanaka T, Ohashi N, Narumi T, Nomura W, Harada S, Matsushita S, Tamamura H*. CD4 Mimics Targeting the Mechanism of HIV. Bioorg. Med. Chem. Lett. 20; 354-358, 2010.
16. 野村 渉，増田 朱美，玉村 啓和：「エピジェネティクな遺伝子発現制御のためのDNAメチル化酵素の創製 「生化学」ミニレビュウ（日本生化学会，東京）, 82 (5), 515-523，2010. 🔗
2009 & previous
15. Tsutsumi H, Nomura W, Abe S, Mino T, Masuda A, Ohashi N, Tanaka T, Ohba K, Yamamoto N, Akiyoshi K, Tamamura H*. Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells. Angew. Chem., Int. Ed. 48; 9164 –9166, 2009.
14. Tanaka T, Nomura W*, Narumi T, Esaka A, Oishi S, Ohashi N, Itotani K, Evans BJ, Wang Z-X, Peiper SC, Fujii N, Tamamura H*. Structure-Activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold: the Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acids. Org. Biomol. Chem. 7; 3805-3809, 2009.
13. Ohashi N, Nomura W*, Kato M, Narumi T, Lewin NE, Blumberg PM, Tamamura H*. Synthesis of Protein Kinase C Delta C1b Domain by Native Chemical Ligation Methodology and Characterization of its Folding and Ligand Binding. J. Pept. Sci. 15; 642-646, 2009.
12. Tanaka T, Tsutsumi H*, Nomura W, Tanabe Y, Ohashi N, Esaka A, Ochiai C, Sato J, Itotani K, Murakami T, Ohba K, Yamamoto N, Fujii N, Tamamura H*. Structure-activity Relationship Study of CXCR4 Antagonists Bearing the Cyclic Pentapeptide Scaffold: Identification of the New Pharmacophore. Org. Biomol. Chem. 6; 4374-4377, 2008.
11. Nomura W, Tanabe Y, Tsutsumi H, Tanaka T, Ohba K, Yamamoto N, Tamamura H*. Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4-Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening. Bioconjugate Chem. 19; 1917-1920, 2008. 🔗
10. Tamamura H*, Tsutsumi H, Nomura W, Fujii N, Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists toward Downsizing. Perspectives in Medicinal Chemistry 2; 1-9, 2008.
9. Tamamura H*, Tsutsumi H, Nomura W, Tanaka T, Fujii N, A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists. Expert Opin. Drug Discov. 3; 1155-1166, 2008.
8. Nomura W, Barbas CF, III*. In Vivo Site-Specific DNA Methylation with a Designed Sequence-Enabled DNA Methylase. J. Am. Chem. Soc. 129; 8676-8677, 2007. 🔗
7. Nomura W, Sugiura Y. Design and Synthesis of Artificial Zinc Finger Proteins Methods in Molecular Biology; Protein Engineering Protocols, Humana Press 352; 83-93, 2007.
6. Hirata T, Nomura W, Imanishi M, Sugiura Y*. Effects of Linking 15-Zinc Finger Domains on DNA Binding Specificity and Multiple DNA Binding Modes. Bioorg. Med. Chem. Lett. 15; 2197-2201, 2005. 🔗
5. Nomura W, Sugiura Y*. Effects of Length and Position of an Extended Linker on Sequence-Selective DNA Recognition of Zinc Finger Peptides. Biochemistry 42; 14805-14813, 2003. 🔗
4. Nomura W, Nagaoka M, Shiraishi Y, Sugiura Y*. Influence of TFIIIA-Type Linker at the N- or C-Terminal of Nine-Zinc Finger Protein on DNA Binding Site. Biochem. Biophys. Res. Commun. 300; 87-92, 2003.
3. Nagaoka M, Shiraishi Y, Uno Y, Nomura W, Sugiura Y*. Interconversion between Serine and Aspartic Acid in the α-Helix of the N-Terminal Zinc Finger of Sp1: Implication for General Recognition Code and for Design Novel Zinc Finger Peptide Recognizing Complementary Strand. Biochemistry 41; 8819-8825, 2002.
2. Nagaoka M, Nomura W, Shiraishi Y, Sugiura Y*. Significant Effect of Linker Sequence on DNA Recognition by Multi-Zinc Finger Protein. Biochem. Biophys. Res. Commun. 282; 1001-1007, 2001.
1. Nagaoka M, Kaji T, Imanishi M, Hori Y, Nomura W, Sugiura Y*. Multiconnection of Identical Zinc Finger: Implication for DNA Binding Affinity and Unit Modulation of the Three Zinc Finger Domain. Biochemistry 40; 2932-2941, 2001.